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Seminar INFLPR, Miercuri, 06.07.2016, ora 11.00, Sectia Laseri, Dr. Adriana Smarandache: „Studierea efectelor radiatiei laser asupra spumelor de polidocanol utilizate in scleroterapia fotodinamica”

Home Import Research Evenimente vechi Seminars Seminar INFLPR, Miercuri, 06.07.2016, ora 11.00, Sectia Laseri, Dr. Adriana Smarandache: „Studierea efectelor radiatiei laser asupra spumelor de polidocanol utilizate in scleroterapia fotodinamica”

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Sunteti invitati sa participati la seminarul stiintific de Miercuri, 06 Iulie 2016, ora 11.00 care va avea loc la sala de seminar din Sectia Laseri si va cuprinde prezentarea dnei Dr. Adriana Smarandache cu titlul „Studierea efectelor radiatiei laser asupra spumelor de polidocanol utilizate in scleroterapia fotodinamica”, raport de faza din luna iunie a proiectului PN 16 47 01 03.

Abstract
Obiectivul cercetarii l-a constituit stabilirea proprietatilor foto- fizice ale agentilor sclerozanti in scopul explicarii mecanismelor de actiune ale acestora in scleroterapia fotodinamica, date fiind rezultatele terapeutice superioare comparativ cu cele obtinute prin metodele clasice. Scleroterapia fotodinamica reprezinta o metoda recent adoptata in tratarea afectiunilor varicoase si presupune combinarea a doua tehnici medicale si anume scleroterapia urmata imediat de terapie laser Nd:YAG. In ultimul timp, medicamentele sclerozante sunt folosite sub forma de spuma, care prezinta o serie de beneficii in comparatie cu injectarea de solutii. Unul dintre cei mai folositi agenti sclerozanti este Polidocanolul, care este un surfactant non-ionic ce apartine grupului de eteri alchil poliglicolici. Acesta constituie elementul activ din medicamentul comercializat sub denumirea de Aethoxysclerol.
Utilizand metoda Tessari au fost preparate diferite probe de spuma; stabilitatea acestora a fost evaluata pe baza timpului lor de viata, precum si prin masurarea tensiunii superficiale dinamice utilizand picaturi suspendate.
Probe de solutii dar si spume de Aethoxysclerol si de Polidocanol in apa/etanol au fost expuse la radiatie laser la 266 nm emisa de un system FHG cuplat cu un laser pulsat cu Nd:YAG. Proprietatile optice ale acestora, inainte si dupa iradiere laser au fost masurate prin metode spectroscopice (absorbtie UV/VIS, FTIR si imprastiere Raman).

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