Contract no.: 30N/12.01.2023
Title: "The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society"
Step 1: "The development of the sub-assemblies and components for laser pulses of sub-picosecond"
Responsible for this: Dr Marian ZAMFIRESCU
The term of the conclusion of the phase: 12.05.2023
Abstract:
The main objective of this phase was the study of various configurations of optical sub-assemblies, and components of the optical and electronic characteristics of the amplifier and laser pulses of sub-picosecond, as well as the realization of the elements of the laser-pumped (the medium-the active laser, the mirrors of the laser) to get the configuration of the system, the laser end. They have been carried out for the first time by the Czochralski method, and were characterized by crystal laser type Nd:LaxGdyYzSc4-x,-y,-z(BO3)4, with the melting incongruentă, and the emission of the laser's effective at 1.06 µm. They have been designed for the configurations of the structure and dielectric Bragg, for making mirrors and laser are obtained, and the characterization of thin films of SiO2, TiO2, and HfO2 deposited by the techniques of PID, value added tax and magnetron sputtering, and were determined the parameters of the optical film made. There have been developed a number of numerical studies based on finite-difference (FDTD) in order to determine the environments, the optimum for the propagation of the laser beam to induce an elongation time of the laser pulse in the field of 0.5 – 1 ps. Also, there have been developed a number of models raytracing for the design of a scheme, the best of the amplifier of the laser in order to achieve a maximum efficiency of the amplifier according to the current requirements in the field of the laser pulse of ultra-short. The target is an intermediate step in the realization of laser sources for the production of advanced additive and subtractive devices for emerging technologies.
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Step 2: "Synthesis and characterization of the active materials used in advanced sensors and sensing"
Responsible for this: Dr Gabriela CHRISTMAS
The term of the conclusion of the phase: 15.07.2023
Abstract:
As part of this step was performed on the synthesis and characterization of materials used in advanced sensors, and detection methods with the laser, plasma and radiation. We have obtained and characterized oxide nanopowders with a low content of carbon by the pyrolysis of lasers, phosphors (SrLaGaO4, Ca3Ta2Ga3O12), ceramic difuzante, and the luminescent material doped with the ions of the lanthanide (Nd3+, Er3+, Ho3+, Yb3+), nanopereți carbon (CNW) are either simple or functionalized by the technique of plasma, and the nanoparticles with or without the magnetic properties (nAg nNi), by irradiation with electrons accelerated to high energy.
For the senzoristicii of the gas have been synthesized oxide nanopowders by using isopropanol and etena as sensibilanți. The use of isopropanol in the form of a vapor, it has led to a decrease in the size of the crystals of SnO2-x, with 23% as compared to the process in which it is used etena. Also, they had come up with nanopulberi of SnxFeyOz of 4.5 nm with the crystallinity, the good, the size of the crystal varies between 3 and 10 nm. For the senzoristicii surface acoustic waves (SAW) have been synthesized TiO2 nano-particles by the method of pyrolysis of the laser in the fumes of TiCl4 in the air and in the presence of ethylene, in varying operating pressures, the average size of the particles, as expected within the range of from 15 to 22 nm.
Also, the obtained phosphors ceramic Er:CaSc2O4 (via the sol-gel method), RE3+:CTGG and the RE3+:SrLaGaO4 (by way of reaction in the solid phase). We have chosen three of the matrix of the host (Y2O3, CaSc2O4, and BaGd2ZnO5) prepared by the method of the reaction in the solid phase, and which have been doped with the three systems, the ions of the lanthanide (Er3+-Yb3+, Ho3+-Yb3+ - and Er3+-Ho3+-Yb3+), resulting in materials with crystallinity of pure, who confirmed the emission, in the area of 500 to 800 nm. The analysis of the structural and morphology have shown the properties of the favorable characteristics of these materials for applications such as temperature sensors, non-contact.
It summarizes the nanopereti of carbon dioxide (CNW) are either simple or functionalized by the techniques in the plasma of RF, in many different kinds of supports, in order to obtain the cell that would stand on its own feet. They have been identified and tested the effects of the CNW, with applications in the field of senzoristicii SAW the gas sensor chimioresistivi and it shows.
The optimization of the process of irradiation by the application of an experimental design, Central Composite Design (circumscribed) – Response Surface Methodology (CCD-RSM), with 20-position, has led to the obtaining of nanoparticles of silver (nAg) to the radiation dose of 17.6 kGy, with a desirability of 0,810. The nanoparticles of nickel (nNi) with the magnetic properties have been obtained at the irradiation dose of 300 kGy, their size varying between 20 and 70 nm of torque.
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Step 3: "The development of methods and protocols for the detection, with applications in smart agriculture"
Responsible for this: Dr Gabriel SOCOL
The term of the conclusion of the phase: 13.10.2023
Abstract:
The contamination of soil with heavy metals is a major concern in terms of pollution to the environment, having a negative impact on the growth of the plant, the quality of the food, and the health of the animals, and the general public. For the achievement of the objectives of this phase of the effort has been focused on the effect of copper, the metal that was used in the pesticides commonly used in agriculture, the impact on the development of the plant and the soil.
Thus, it was investigated the effects of contaminated soil on the plants grown in this medium. In order to identify the concentration of copper in soil samples, were used in spectroscopy techniques, Laser-Breakdown Induced Spectroscopy, and Time-Domain Spectroscopy in the THz domain, by developing the two protocols for the detection of contaminants in the soil. It has been developed and used in a growth chamber with dimensions of environmental control for the study, 125 plants, then Data were grown in the contaminated soil. The light conditions, temperature, and moisture content of the soil was kept constant, being monitored, the effects of copper on these plants, with the help of UV-VIS spectroscopy and imaging Investigations. In this respect, we have developed a specific protocol for the monitoring of the effects of the samples from the contaminated soil, the plants, by using these two techniques complement each other.
At the same time, he developed a protocol for germination contained the seeds of common wheat were determined from the concentrations of ethylene and ammonia in the breath of the germ of the wheat (Triticum aestivum) by using the technique of spectroscopy fotoacustică with a laser beam. The contamination has been carried out in a controlled using a solution of CuSO4 at concentrations in molar ratio of 1 µM, 100 µM, 1 mM and 10 mM. On the other hand, we have studied the effect of the remediation of the hidrogelului the geremenilor of wheat germinate in the soil mixed with the hidrolgel, and two different types of food. Thus, the same technology absorption spectroscopy has been applied to the evaluation of the influence of the contaminants from the type of heavy metals on germination, rooting, rising, and the fellowship of the seed of the wheat in the ground, and the hydrogel was observed beneficial effect of bioremediation on the seedling emergence of wheat.
During this phase, there have been developed: i) a protocol for the determination of the sensitivity of the sensor to the FO-SPR coated with gold, using a two-fold dilution of the sucrose with a refractive index for the met, and ii) a protocol for the FO-SPR on the basis of reflection, covered in gold-functionalized with PANI, which is able to detect Cu2+ in deionized water, with a sensitivity of 2379 nm/mM, and a LOD of 0.35 µM.
These studies have contributed to our understanding of the impact of the contamination with heavy metals on the environment and provide cost-effective methods of detection.
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Stage 4: "Job-state lasers, plasma and radiation damage of the structures, biomaterials, implants, and wound dressings Loaded with the chemotherapeutic drugs"
Responsible for this: Liviu-Marian DUTA, Alexandra PALLA-PAPAVLU
The term of the conclusion of the phase: 08.12.2023
Abstract:
At present, there is a significant application for the manufacture of a medical device intended for application in regenerative medicine, which is part of the advance of personalized medicine. In this context, the technology behind the stent biliary disease is becoming an essential element that contributes to the successful implementation of the procedures for liver transplant recipients, and facilitate the rapid recovery of the patient. In this context, we report the fabrication of a new design of the device is a stent in the bile, based on polycaprolactone (PCL), fully resorbable, primarily designed to support the functions of the bile duct in the post-liver transplantation. We present the results of a study investigating the effects of time and speed of centrifugation on the morphology of thin films of PT produced by the coverage of the centrifuge. In the end, the PCL has been divided by the irradiation with the radiation of the laser polarized linearly.
X-ray diffraction patterns GIXRD of the layers of the thin BioCaP summary showed that the presence of a single phase of HA-type socket. It has been observed that the degree of crystallinity of the structures of the synthesised has been affected by the deposition parameters. The FTIR spectra showed the existence of bands of the phosphate group, the specific structure of HA, okay, crystal. This result is in agreement with the observations of GIXRD. The results of the investigation, the SEM has been demonstrated in the synthesis of surface morphology is rough and rugged, consisting of the parties (" particulate matter ") from the shape of the ball, or even ovoid, with different sizes. SEM images of cross section are shown in all cases, the coatings are uniform, with an increase in the type column. In contrast to the control, for which he recorded the behavior of a water-repellent, in the case of the layers of the thin-BioCaP was observed behavior of a hydrophilic. The values obtained from the tests of the bonding strength was higher than those required by the standards in force (>15 MPa).
I've got two different types of composite biomaterials functionalized: PVP ciclopirox / caspofungin acetate. Nanomaterials have been put together in the form of thin films by the method of evaporation, pulsed laser-assisted matrix (MAPLE) on substrates of silicon and the optical glass. Movies the thin deposited by the MAPLE leafs have been characterized by AFM and ft-IR.
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Phase 5: "The manufacturing of the laser to be additive, and the texture of the structures made of biocompatible materials"
Responsible for this: Irina PAUN, Andrei POPESCU
The term of the conclusion of the phase: 08.12.2023
Abstract:
Faza 5 a proiectului a vizat fabricarea laser aditivă și texturarea laser de structuri din materiale biocompatibile. Pentru indeplinirea acestui obiectiv, au fost planificate si realizate 3 activitati, toate avand aplicatii directe in domeniul biomedical. Activitatea de fabricare laser aditiva prin metoda Topirii Laser Selective a avut ca rezultat obtinerea de substraturi medicale si dispozitive de tipul protezelor de sold plecand de la un material de baza sub forma de particule sferice din aliaj de Ti gradul 5 (Ti6Al4V) cu diametre intre 20-63 μm. Pentru obtinerea unor structuri dense, fara defecte de interior, principalii parametrii de procesare au fost: 200 W puterea laser, la o viteza de procesare de 2 m/s, un strat avand grosimea de 20 μm. S-a identificat o structura metalografica de tip Widmanstatten, cu dendrite de faza α hexagonal compacta crescute pe doua directii perpendiculare intr-o faza β cubic cu volum centrat. Aceste rezultate vor putea fi scalate in vederea utilizarii in aplicatii de inginerie medicala, mai precis pentru o gama larga de implanturi perosnalizate. Forma si dimensiunile produselor individualizate vor putea fi obtinute utilizand instrumente de scanare 3D cu raze X (tomografii ale pacientilor). O alta activitate a constat in realizarea unui protocol de fabricare laser aditiva prin metoda scrierii directe cu laser prin fotopolimerizare cu 2 fotoni a unor structuri 3D cu arhitecturi biomimetice, pe bază de polimeri biocompatibili, in vederea unor aplicatii in ingineria tesutului osos. Motivatia pentru acest studiu s-a bazat pe faptul ca manipularea materialelor biologice la nivel celular constituie un domeniu de cercetare de mare actualitate pentru aplicatiile biomedicale. In cadrul acestei activitati, structuri sub forma unor micro-recipiente au fost fabricate utilizând scrierea directă cu laser prin polimerizare cu doi fotoni a unui compozit pe baza de fotopolimer biocompatibil si nanoparticule superparamagnetice pe baza de de oxid de fier. Structurile obtinute au fost caracterizate din punct de vedere structural si testate in culturi de celule de tip osteoblast. Structurile însămânțate de celule si expuse la câmpuri magnetice statice de 1.3 T au fost de aproximativ 5 ori mai eficiente în ceea ce privește captarea celulelor, in comparatie cu structurile nestimulate in camp magnetic, demonstrandu-si potențialul pentru ingineria tesutului osos. A treia activitate derulata in cadrul Fazei a vizat tot domeniul biomedical, mai precis dezvoltarea de tehnologii asitate laser inovatoare pentru imbunatatirea eficacitatii dispozitivelor implantabile. Aceasta activitate a explorat dezvoltarea unui model experimental de microprelucrare cu laser cu excimer prin proiectie cu masca, si replicare, a unor suprafete microstructurate (PLGA, chitosan, PCL, Zirconia), care au fost testate si validate in vitro in culturi de celule si pentru care s-a obtinut un raspuns biologic preliminar. Aceasta abordare a deschis noi perspective in dezvoltarea dispozitivelor implantabile personalizate cu potential de integrare si compatibilitate biologica imbunatatite, contribuind la progresul aplicatiilor biomedicale.
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