Contract no.: 30N/12.01.2023
The project: "The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society"
The phase 6/2024: "The techniques and devices advanced analytics for personalized medicine"
Responsible for this: Dr - Felix SIMA
The term of the conclusion of the phase: 09.05.2024
Abstract:
At this stage, I have been following the development of new methods and techniques of analysis for personalized medicine. There have been three studies in order to achieve this goal.
• In a first study, we showed that the techniques for processing with a laser pulse of ultra-short-materials allow you to improve the resolution of the micro - and nano-manufacturing, and it has the advantage of obtaining some of the issues with the size of the hierarchy as compared to the techniques of lithography. In addition, I managed the integration of the systems of the micropompaj in microfluidic production of electrodes of ITO, with a controlled size. Devices, microfluidic, and nanofluidice offers solutions that are ideal for the observation of the ability of cancer cells to migrate through tight spaces, which mimics the processes of the intravazare-extravasation from the in vivo studies.
• Am analizat caracteristicile specifice ale unei amprente digitale, folosind pulberi Er(x%):BGZO. Obiectivul acestui al doilea studiu a fost prepararea unui material stabil chimic si termic, cu proprietati luminescente deosebite, pentru conversia superioara la puteri mici de pompaj in infrarosu apropiat. In acest scop, am investigat proprietatile de emisie prin conversie superioara in verde, a materialului de tip BGZO dopat cu ioni de Er3+. Cele mai promitatoare rezultate au fost obţinute pe proba de BGZO dopata cu 4 at% Er3+. Studiul reziduurilor lasate de suprafata degetului pe o lamela da posibilitatea de a utiliza amprenta digitala in medicina personalizata, reflectand tranzitia de la un model „one-size-fits-all” la unul personalizat si dinamic.
• The research in this study has been focused on three different types of cancer, in the field of ENT: squamous cell carcinoma microinvaziv at the level of the hemibazei of the tongue squamous epithelium-mioepitelial with the activity of the mitotic focal increased to the level of the floor of the maxillary sinus, and squamous cell carcinoma poorly keratinizant G3 at the level of the hemilimbii. The obtained data contribute to the identification of the significant parameters, such as the intensity of the maxima of the fluorescence, and time-to-live, you autofluorescenței, which can be used in the discrimination between healthy tissues and malignant tumors in the field of ENT. Thus, the integration of the analysis of the autofluorescenței, and of ft-IR should be able to improve the ability of the diagnosis and characterization of neoplastic hearing aid, with a great potential in the field of medicine.
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Contract no.: 30N/12.01.2023
The project: "The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society"
The phase 7/2024: "The completion and testing of the components of photonics and electronics of the control system of the laser pulses of sub-picosecond"
Responsible for this: Dr Nicholas PAUL
The term of the conclusion of the phase: 06.06.2024
Abstract:
• As part of this phase of the contract, has been obtained the emission of the laser efficiency (at 1062 nm) and a crystal came to pass, When ThexGdyYzSc4-x-y-z(BO3)4 (Nd:LGYSB), using the pumping of the optical diode lasers. It has been investigated in the regime of the operating system free with the pumped quasi-continuous and continuous.
• We have obtained and investigated in a sample of the ceramic-type Ca3(Li,Ta,Ga)5O12 – (CLTGG) doped with different concentrations of Tb3+. It has been estimated the effective emission at 542 nm, the value obtained (2.54×10-21 cm2) indicate that the type of CLTGG:Tb (15 at.%) it may be a potential environmental asset for the emission of the laser, at 542 nm of torque. They have been obtained and investigated in the samples of ceramic co-doped type-CLTGG:Tb (15 at.%), Yb (y, at.%). They are made with the identification of emission of Tb3+ in the visible spectrum, with excitation in the infrared (at 973 nm). The environment of the ceramic doped with Tb (15 at.%), Yb (5 at.%) the most intense line emission at 542 nm of torque.
• They were obtained by the average of the ceramic, transparent, composite-type Y2O3/x-at.% The Nd:Y2O3 (x= 0.5, 1.0, 1.5), and Y2O3/y at.% The Yb:Y2O3 (y= 3.0, 5.0, 8.0), by reaction in the solid phase sintering, in several stages. The averages of the ceramic shows a high quality that is confirmed by the results obtained from the investigation of the structural, morphological, and optical.
• They've been made out of mirrors of the laser at 532 nm by the deposition of thin films of TiO2 and SiO2 on the substrate by the quartz crystal by the method of RF-magnetron sputtering. They were obtained by the mirrors of the laser, with the 7th, the 11th and the 17th of the layers, using the substrate of the industrial office. All of the videos submitted, presented the the very best quality in terms of surface roughness, villosities, measured by AFM, profilometrie and elipsometrie is of the order of the subnanometric up to a few nm. It was carried out a parametric study in order to optimize the obtaining of reproducible, mirrors, Bragg (heterostructures of TiO2/SiO2/TiO2/SiO2/TiO2/SiO2/TiO2 layers on a substrate of quartz crystal) on a large area by the submission of the laser-pulsed (PLD and RF-PLD), covering the reflectance at a wavelength of 532 nm. It has been obtained by PLD and RF-PLD heterostructures containing a 7-alternating layers of SiO2/TiO2 layers on a substrate of silicon, thick, and dense, with a surface roughness is very small~3 nm of torque (IT) and ~9 nm (AFM)]. They have been made structures such as multi-layer (TiO2/SiO2)×3 (TiO2/SiO2)×7, using the method of the VAT rate in the controlled atmosphere of oxygen.
• It has made the design of the system, the laser pulses of sub-picosecond, and a system of command-and-control for (a block diagram of the overall control including the timing, selection, and implementation; the structure of the system of command and control, interfaces, input and output).
Abstract this graphic:
Contract no.: 30N/12.01.2023
The project: "The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society"
The phase 8/2024: "The integration and characterization of the structures of the sensors"
Responsible for this: Dr Alexandra Palla-Papavlu
The term of the conclusion of the phase: 26.07.2024
Abstract:
The agriculture of today is faced with many challenges, including a lack of manpower, the unpredictability of the climate and the soils are poor in the case of the management of scarce land. In order to address these issues, the technology provides the solutions through the development of sensor platforms for the detection for smart agriculture. This project focuses on the development of technologies for the fabrication of sensors and platforms for sensing, covering both smart agriculture, as well as the safety of the public, along with the monitoring and quality control of manufacturing processes advances.
Within the framework of the project have been achieved in experimental models of sensors with thin films of the solid solutions piezo-electric, for the detection of gases such as CO2 and NH4. Thin layers of barium titanate (BaTiO3) have been deposited on ceramic substrates of alumina (Al2O3) by the laser ablation (PLD) and characterized for their morphological, chemical, and electrical. The tests showed jumps in a significant frequency in the presence of the gas, thus demonstrating the importance of the deposition parameters.
Also, we have fabricated sensor conductometrici on the basis of metal oxides (SnO2-ZnO), and polianilină (PANI) for the detection of methane in the temperature of the room. The electrodes of the metal from the platinum was deposited by sputtering, and the sensitive material has been added by the PLD, and curing the oxidative chemical (PANI).
The technique of the LIFT (transfer of the laser-induced forward) has been used to fabricate sensors, chemorezistivi-based materials, organic-inorganic hybrid (PEDOT:PSS-GO). This technique has allowed for the transfer of a specific material on a substrate receptor, resulting sensors are able to detect NO at room temperature.
In order to improve the chemical and physical properties of the sensor, we used the γ-irradiation with a beam of accelerated electrons. This process was performed with a linear accelerator of electrons, and the dosimetry was accurately monitored by using the calorimeters of the lead and the film radiocromice B3, calibrated in accordance with the international standards.
In conclusion, this phase has demonstrated success in the development and characterization of advanced sensors for smart agriculture. The use of technology such as a PLD, an ELEVATOR, and the irradiation of the electron beam of the led to the production of sensors, adaptable, able to respond quickly and effectively to the presence of the gas of interest. These achievements can make a significant contribution to the improvement of the monitoring and control of the processes of agriculture, and promoting the agriculture more efficient and sustainable.
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Contract no.: 30N/12.01.2023
The project: "The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society"
The phase 9/2024: "Study of the analytical and experimental results for the optimization of the properties of the nanofluidelor magnetic-functionalized compounds for antitumor"
Responsible for this: Dr Florian DUMITRESCU, Phd. Angela STAICU
The term of the conclusion of the phase: 07.11.2024
Abstract:
S-au investigat nanoparticule de oxid de fier preparate prin piroliza laser folosind diferiți senzitivanți: etilena (NPs), izopropanolul (i-NPs) și etanolul (eNPs). Analizele morfo-structurale confirmă prezenta unui material nanometric de dimensiuni reduse, cvasi-sferice cu o tendinta de aglomerare înlănțuită. Toate pulberile au prezentat o stabilitate ridicată în apă și o dimensiune a diametrului hidrodinamic redusă. S-au realizat stabilizări/functionalizari cu dextran, CMCNa, Decarbazina si Acid Folic și optimizări ale acestor protocoale. Tratarea termica a nanoparticulelor este realizata pentru a genera acestora proprietati magnetice ridicate, peste valoarea specifica a celor proaspat sintetizate, dar fara a compromite capacitatea lor de suspendare. Nanopulberi de γ-Fe2O3 sunt sintetizate prin piroliza laser folosind etanolul ca senzitivant, ulterior acestea sunt tratate termic la 250oC, 3h în flux constant de gaz: aer, Ar, hidrogen. Modificarile structurale sunt minime daca tratamentele sunt facute in Ar sau aer, insa dimensiunea de cristal creste semnificativ, de la 5.2nm netratate la 13.0nm pentru NPs tratate in hidrogen. Nanofluidele preparate cu aceste NPs in apa prezinta o excelenta stabilitate in timp; testarea s-a facut dupa 1h si 24h de la preparare; dimensiunea de aglomerat este de c.c.a. 100nm si potentialul Zeta peste 45mV. Tratamentele termice afecteaza rezonabil de putin stabilitatea in timp, insa diminueaza potentialul Zeta.
They have been studied in emulsions, including fotosensibilizatorul of the TPP-SO3Na-and nano-particles of e-Service, i-NPs, NPs loaded with Dacarbazine. They have been analyzed from the point of view of morphological, structural and physico-chemically by the special investigation unit, absorption spectroscopy, UV-Vis, ft-IR, TOP, phosphorescence of singlet oxygen is generated, and the analysis of the surface tension of the dynamic.
The results of DLS showed that the emulsion size is stable, the droplets are between 150-170nm, which remains constant for the duration of the experiments, indicating that the stability is very good. The stability of the emulsions was confirmed by the analysis of ft-IR-ATR. One of the emulsions considered, the challenge to the stability of the was the emergence of the TPP-SO3Na+and-Service.
The tests for the generation of singlet oxygen, they found a significant amount of time, the intensity of the signal from the stuff of the latter in the emulsion as compared to the simple out of the TPP-SO3Na. The analysis of the dynamics of the surface tension indicates that there is a migration of a significant particles of the dispersed phase to the surface by the coalescence of droplets of the oil and the emulsion leaves a uniform and stable.
In conclusion, the emulsions studied the embedding of the nanoparticles shows a remarkable stability and can increase the rate of generation of singlet oxygen, which is what I recommend for the potential applications in the therapy pdt for the efficient delivery of the drug.
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Contract no.: 30N/12.01.2023
The project: "The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society"
The phase 10/2024: „Optimizarea proceselor tehnologice de sinteză și fabricare a elementelor componente pentru stocare de energie – partial etapa I”
Responsible for this: Dr Mihai ZAMFIR, Phd. Nick SCĂRIȘOREANU
The term of the conclusion of the phase: 22.11.2024
Abstract:
Metoda de piroliză cu laser a fost folosită pentru sinteza materialelor anodice fără Co pentru bateriile cu ioni Li sau Na, bazate pe amestecuri controlate de nanoxizi de staniu (SnO2 și SnO) pornind de la Sn(CH3)4 și folosind senzitizer/purtător C2H4 în prezența diferitelor fluxuri de O2 (+N2). Proprietățile morfostructurale, compoziționale și de dispersie in lichideau fost raportate folosind tehnici XRD, EDS, XPS, TEM si DLS – Potential Zeta
Metoda substratului acoperit cu catalizator (CCS) a fost folosită pentru fabricarea MEA pentru PEMFC. Straturile de difuzie a gazelor (GDL) sunt construite întâi prin acoperirea hârtiei din fibră de carbon corespunzatoare ca dimensiuni cu straturi mezoporoase (MPL) formând suspensii de nanoparticule de carbon în izopropanol cu o cantitate mică de perfluoretilenă hidrofobă prin pulverizare aerograf. Apoi, straturile catalitice (CL) realizate din piroliză comercială sau laser au făcut nanoparticule pe bază de carbon decorate cu diferite cantități de particule ultrafine de Pt pentru catod și anod și adăugate cu fluoropolimer sulfonat sunt pulverizate peste MPL-urile din dispersii. În cele din urmă, membrana electrolit polimeric comercial este presată la cald între cele două CL susținute pe GDL pentru a obține un MEA funcțional.
Calcogenurile of the transition metals (TMCs) stands out as one of the most interesting candidates for both fundamental research and potential applications in the field of energy in the body. Their synthesis in the form of nanostructurată and architecture, straight, with carbonaceous materials have enormous potential, mainly due to the high ratio between surface area and volume, which provides a space for accommodating the volume changes during cycles of loading and unloading, while promoting at the same time, the transport of the ion-quick and interactions of the short distance between the load, which allows for a high rate of charge/discharge. For the realization of these architectures, nanostructured materials have been used, the methods and techniques with a high degree of scalability, and the potential for the transfer of technology partners in the industry: the plasma of the Arc-type Thermionic Vacuum tax (VAT), the deposition of the vapour-assisted laser (LCVD) and sulfurizarea of the hot spring.
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