Contract no.: 30N/12.01.2023
The project: "The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society"
The phase 13/2025: "Experimental and analytical work for the development of wound dressings for the type of hydrogel loaded with chemotherapeutic drugs"
Responsible for this: Dr Maria DEMETER, Phd. Angela STAICU
The term of the conclusion of the phase: 09.04.2025
Abstract:
Multifunctional systems for the administration of drugs with a new strategy in the treatment of the target in cancer, as these will give you the advantage to the administration of chemotherapeutic agents, without damage to cells and tissues healthy. In this paper, we developed and characterized for the new polymer compositions of the obtained poly(vinilpirolidonă), carboxy methyl cellulose, poly(ethylene glycol), agar gum, gellan for the development of wound dressings in the form of a hydrogel loaded with chemotherapeutic drugs. Hidrogelurile have been simultaneously synthesized (cross-linked), and sterilized by irradiation with the electron beam at a dose of 30 kGy. To demonstrate the functionality of the hidrogelurilor developed countries has been achieved through the analysis, sol-gel, the efficiency of the process of cross-linking, swelling properties in a physiological environment, and the tumor simulated, with a capacity to hold moisture, structural analysis (ATR-FTIR), rheological properties, degradation in vitro, the ability to load anticancer drug (5-FU) and the profile of the in vitro release of 5-FU. The kinetics of the release of 5-FU have been investigated using a mathematical model commonly used in the design of pharmaceutical drugs. After the irradiation, the hidrogelurile are a fraction of the gel is 90%, and the cross-linking process is predominant. The high values of the yield radiochemical cross-linking (330 µmol/J), a 16-fold higher than those from the decay of (20 µmol/J), confirming the formation of the hydrogels cross-linked with the role of the main character after the irradiation. The environment of the swelling significantly influence the degree of swelling, and the ability to charge with the 5-FU hidrogelurilor. In an alkaline medium, the absorption capacity is 980-1090 %, and the pH is significantly higher, 1380-1580 %. Hidrogelurile preserve approximately 48% of its moisture for up to 8 hours, more than enough time to ensure the functionality of it as the dressing for type in the hydrogel. The analysis of the rheological showed that the hidrogelurile have a behavior that is predominantly elastic, specifically a network of high molecular weight cross-linked (F’ = 3 450-54 000 Pa). The capacity of the optimum loading of 5-FU, varies as a function of pH, time of upload, the composition of the hidrogelului, and the concentration of 5-FU, 200 mg/L of 5-Fu and 30% at pH 6, and 29% at a pH of 5. The release of 5-FU was slow at pH 7.4, making it gradually up to 80% full in 30 hours, depending on the composition of the hidrogelului. The kinetics of the in vitro release of 5-FU correlated best with the kinetic models, Korsmeyer-Peppas, Peppas-Sahilin and the Makoid-Banakar (R2 > 0.99) and demonstrated that the release of 5-FU is governed primarily by the mechanism of accelerated, followed by a mechanism that is controlled by the diffusion process.
The experimental results demonstrate that the hidrogelurile obtained by the irradiation of the claim to the loading and the release of anti-cancer drugs and have the potential to be used as a dressing for the local treatment of cancer.
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Contract no.: 30N/12.01.2023
The project: "The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society"
Faza 14/2025: „Validarea modelelor și metodelor de analiză pentru caracterizarea plasmei de fuziune în sistemele tokamak destinate producerii de energie”
Responsible for this: Dr. Eduard GRIGORE, Dr. Gabriel MIRON
The term of the conclusion of the phase: 09.06.2025
Abstract:
The aim of this work is to acknowledge the way the initial width of the magnetic island associated to the neoclassical tearing modes (NTM) affects the derivation of the NTMs amplitude and frequency. The proposed theoretical model we use has to be previously tested and validated in order to obtain the best match between the modelled and experimental modes amplitude, frequency and location especially. Because of this, a new method for the localization of the perturbations based of the knowledge of its amplitude is briefly presented. Relying on the successful testing of the perturbations model (Miron I.G. and JET Contributors 2021, Nucl. Fusion 61, 106016) against the experimental results at JET, its reversed implementation is applied in order to derive the location of the modes. The experimental mode amplitude plays, this time, the role of the input data with the aim to conversely obtain the perturbations location. The calculated location accuracy is conditioned by a good theoretical retrieval of the experimental mode amplitude and frequency. Based on the chosen initial conditions, the desired location is the one associated to the best possible mentioned retrieval. Our model reliability basically ensures the derivation of the suitable location. No safety factor and plasma rotational velocity data profiles are used. The method has been extensively tested and checked in order to become a valid alternative to the usual localization techniques.
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Contract no.: 30N/12.01.2023
The project: "The development of innovative solutions and technologies for the manufacturing of advanced laser, plasma and radiation for solving the problems of society"
Faza 15/2025: „Construirea și caracterizarea ansamblului laser sub-picosecunde„
Responsible for this: Dr Nicolaie PAVEL
The term of the conclusion of the phase: 14.07.2025
Abstract:
In this phase of the contract, two types of composite transparent ceramic media were obtained: two-layer media with x-at.% Y2O3/y-at.% Yb:Y2O3 (x = 0, 3, 5; y = 3, 5, 8) as well as three-layer media with gradually increasing concentrations of Yb3+ ions (3-at.% Yb:Y2O3/5-at.% Yb:Y2O3/8-at.% Yb:Y2O3) and Nd3+ ions (0.5-at.% Nd:Y2O3/1.0-at.% Nd:Y2O3/1.5-at.% Nd:Y2O3). This was achieved by solid-state reaction and multi-step sintering method. We used micron-sized, commercially available powders of Y2O3 (99.999%), Yb2O3 (99.998%), Nd2O3 (99.999%), La2O3 (99.999%), and ZrO2 (99%). 10-at.% La2O3 and 1-at.% ZrO2 were used as sintering additives to enhance the sintering ability of the compacted ceramic green bodies. The multilayer ceramic bodies were obtained by direct dry pressing of powders gradually doped with laser-active ions and, respectively, of doped and undoped ones. The sintered ceramic media present a good quality, confirmed by the results obtained from structural, morphological and optical investigations. The Yb³⁺-doped multilayer ceramic samples were tested for laser emission at 1.03 m. In the case of the 0-3 Yb sample, laser pulses with slope efficiency of ηsa= 0.31 were generated, reaching a maximum energy of Ep= 1.25 mJ. The Nd:Y2O3 composite medium was tested for laser emission generation at 1.07 m. Laser pulses with energy Ep= 0.95 mJ were obtained for an absorbed pump energy of Eabs= 7.95 mJ; the slope efficiency was ηsa= 0.15. The results validate the feasibility of using the Yb:Y₂O₃ and Nd:Y2O3 multilayer ceramic media in laser applications, while highlighting the importance of optimizing the laser resonator and the active ion concentration to increase the laser performance. The operating and control system of the sub-ps laser was realized, implementing a functional, flexible solution by using an industrial microcontroller from the ATMEGA2560 family, local implementation of the conversion stages and signal delay and the use of a dedicated stage for signal demultiplication. The configuration of the laser amplifier system for pulses with a duration of less than a picosecond was established, for which several subassemblies were developed, as follows:
a) pulse selection train generation system, controllable in the kHz range, from an 80 MHz frequency train delivered by standard commercial femtosecond laser oscillators;
b) multi-pass amplifier with a simplified three-mirror structure;
c) an optical pumping system and an electronic system for controlling the synchronization signals and controlling the entire laser system.
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Contract no.: 30N/12.01.2023
Proiectul: Dezvoltarea de solutii inovatoare si tehnologii de fabricație avansată cu laseri, plasmă și radiații pentru rezolvarea problemelor societale
Faza 16/2025: Testarea și optimizarea in situ a platformelor de detecție cu aplicații în agricultură și siguranța alimentară
Responsible for this: Dr. Iulia ANTOHE, Dr. Gabriel SOCOL
Termen de încheiere a fazei: 09.09.2025
Abstract:
A series of spectroscopic experimental methods and models were developed and tested to provide precise and rapid monitoring of plant health and agricultural product quality. An experimental optoacoustic and THz evaluation model was implemented to study the impact of harmful factors on the quality of fruits and vegetables, allowing the tracking of stress-induced chemical and structural changes. Spectroscopic analyses corresponding to emission transitions in the VIS-NIR range enabled the investigation of dopant ions in luminescent materials, contributing to the development of sensitive indicators for monitoring crop status.
Additionally, a methodology was developed to determine the concentrations of ethylene and ethanol emitted during the ripening and degradation processes of indigenous fruit varieties using photoacoustic spectroscopy, providing a real-time tool for evaluating physiological processes. In parallel, spectroscopic analyses were conducted on agricultural plant samples to determine specific vegetation indices, demonstrating the effects of three stress factors on the studied plants. In the field of crop protection, an experimental model for identifying various categories of pesticides with detection limits in the nanomolar range was implemented using a fiber-optic plasmonic system. Experimental setups were also developed for the spectroscopic characterization of phosphors, alongside with specific protocols for the plasmonic detection of nitrophenolic and organophosphorus pesticides.
In conclusion, spectroscopic methods were developed for monitoring the influence of harmful factors on the ripening and degradation processes of fruits, as well as in-situ methods for assessing the effects of stress factors on agricultural plants. The results obtained demonstrate the establishment of a complex, integrated experimental framework that enables the evaluation of crop status, significantly contributing to the advancement of intelligent, sustainable, and safe agriculture through the provision of precise tools for monitoring environmental stressors and contaminants.
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