Schema de realizare a proiectului 23 03 01 - Anul 2024 - Etapa I
Contractul nr.: 30N/12.01.2023
Proiectul: "Dezvoltarea de solutii inovatoare si tehnologii de fabricație avansată cu laseri, plasmă și radiații pentru rezolvarea problemelor societale"
Faza 1/2024: "Tehnici și dispozitive avansate de analiză pentru medicina personalizată"
Responsabil fază: Dr. Felix SIMA
Termen de încheiere a fazei: 09.05.2024
Abstract:
In this project we have developed techniques and advanced analytical methods for personalized medicine. Three studies have been carried out to this purpose.
In a first study, we have demonstrated that material processing techniques with ultra-short laser pulses allow improving the micro- and nano-fabrication resolution with the advantage of building hierachical geometries as compared with lithography techniques. In addition, we have succeded the integration of micropumping systems inside microfluidic devices by fabricating ITO electrodes with controlled dimensions. Microfluidic and nanofluidic devices offer ideal solutions for observing cancer cells ability to migrate in cnarrow spaces that mimic intravasion-extravasion processes similar with in vivo micro-environment.
In the second study, have analysed the distinct characteristics of a digital fingerprint, using Er(x%):BGZO powders. The goal of this study was to develop a chemicaly and thermaly stable material, with special luminescence properties, for superior conversion at low pumping powers at near infrared. To this purpose, we investigated the emission properties by superior conversion in green of BGZO material dopped with Er3+ ions. The most promising results were obtained for BGZO sample dopped with 4 at% Er3+. The study on residues of finger surface may give the possibility to use digital fingerprint for personalized medicine, reflecting the transition from the model "one-size-fits-all" to another personalized and dynamic model.
The research in the third study focused on three different types of cancer in the ORL sphere: microinvasive squamous cell carcinoma at the base of the tongue, epithelial-myoepithelial carcinoma with increased focal mitotic activity in the maxillary sinus, and poorly keratinized squamous cell carcinoma G3. The obtained data contribute to identifying significant parameters, such as the maximum fluorescence intensity and autofluorescence lifetime, which can be used in discriminating between healthy and malignant tissues in the ORL sphere. Thus, integrating autofluorescence analysis and FTIR spectroscopy could improve the diagnostic and characterization capacity of ORL conditions, holding significant potential in the medical field.
Abstract grafic:
Contractul nr.: 30N/12.01.2023
Proiectul: "Dezvoltarea de solutii inovatoare si tehnologii de fabricație avansată cu laseri, plasmă și radiații pentru rezolvarea problemelor societale"
Faza 7/2024: "Realizarea și testarea componentelor fotonice și electronice de comandă pentru sistemul laser cu pulsuri sub-picosecunde"
Responsabil fază: Dr. Nicolaie PAVEL
Termen de încheiere a fazei: 06.06.2024
Abstract:
During this stage of the contract, efficient laser emission (at 1062 nm) was obtained from a Nd:LaxGdyYzSc4-x-y-z(BO3)4 (Nd:LGYSB) crystal, using optical pumping with a laser diode. The free-running operation regime, under quasi-continuous and continuous pumping, was investigated.
Ca3(Li,Ta,Ga)5O12 - (CLTGG) type ceramic samples doped with variable concentration of Tb3+ were obtained and investigated. The effective emission cross section was estimated at 542 nm; the obtained value (2.54×10-21 cm2) indicates that a CLTGG:Tb type crystal (15 at.%) can be a potential active medium for laser emission at 542 nm. CLTGG:Tb (15 at.%), Yb (y at.%) type co-doped ceramic samples were obtained and investigated. Emission spectra of the Tb3+ ion were performed in the visible range with infrared excitation (at 973 nm). The ceramic medium doped with Tb (15 at.%), Yb (5 at.%) presented the highest intensity for the emission line at 542 nm.
Transparent Y2O3/x-at.% Nd:Y2O3 (x= 0.5, 1.0, 1.5) and Y2O3/y-at.% Yb:Y2O3 (y= 3.0, 5.0, 8.0) composite ceramics were obtained by solid-state reaction and multi-step sintering method. The ceramic media presents a good quality, confirmed by the results obtained from the structural, morphological, and optical investigations.
Laser mirrors at 532 nm were made by depositing thin films of TiO2 and SiO2 on quartz substrates by the RF-magnetron sputtering method. Laser mirrors with 7, 11 and 17 layers were obtained using industrial quartz substrates. All the deposited films showed very good quality in terms of roughness, the roughnesses measured by AFM, profilometry and ellipsometry being of subnanometric order up to a few nm. A parametric study was carried out to optimize the reproducible obtaining of Bragg mirrors (heterostructures TiO2/SiO2/TiO2/SiO2/TiO2/SiO2/TiO2 on quartz substrate) on a large area by the pulsed laser deposition technique (PLD and RF-PLD), targeting the reflectance at the wavelength of 532 nm. By PLD and RF-PLD heterostructures containing 7 alternate layers of SiO2/TiO2 on silicon substrate, dense and compact, with a very low roughness [~3 nm (SE) and ~9 nm (AFM)] were obtained. Multilayer structures (TiO2/SiO2)×3 and (TiO2/SiO2)×7 were made using the TVA method in an oxygen-controlled atmosphere.
The design of the sub-picosecond pulsed laser system and the related command and control system (global control block diagram including synchronization, selection and execution elements; structure of the command and control system; input and output interfaces) was carried out.
Abstract grafic:
