FORMULA FOR INCREASING ADHERENCE OF PEG-BASED COATINGS PREPARED FROM AQUEOUS SOLUTIONS, TO THE SURFACE OF TITANIUM IMPLANTS

The invention relates to a process for preparing coatings adhering to the surface of titanium implants, to be used in biomedical applications. According to the invention, the process comprises the synthesis of 3D structures as aqueous solution containing 4% composite polymeric spheres based on a usual copolymer-polyethylene glycol (PHVB-PEG) wherein the bone morphological protein (BMP4) has been embedded, over which 0.3 g PEG, 8 ml of ethanol, 0.5 ml of vascular endothelium growth factor (VEGF) and 0.5 ml of fibroblastic growth factor 2 (FGF2) have been added in an ethanol : aqueous PEG solution ratio of 4:1, after which the resulting aqueous solution is deposited, using the immersion technique, onto the surface of the titanium implants, to result in thin-layer coatings with high adherence and coating uniformity.